Lymphopenia-Induced Proliferation Lymphocytes during and after Effects of Increasing IL-7 Availability on
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Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia.
Lymphopenia-induced proliferation (LIP) is a proliferative program initiated in response to T cell insufficiency caused by acute or chronic immunodepletion. Studies of lymphopenic mice have demonstrated that the cytokine IL-7 and TCR signaling are critical for LIP. We examined how these two factors impact T cell proliferation following transfer into moderately lymphopenic mice. In this study, w...
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